Document 1
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
2344
29/05/1990
45
Mefloquine Hydrochloride -Suspected
Coordination abnormal
Malaise
Tremor
64106
12/01/1990
21
Mefloquine Hydrochloride -Suspected
Chills
Headache
Lymphadenopathy
Nausea
Myalgia
Abdominal pain
Confusional state
64329
08/02/1990
??
Lariam (Mefloquine Hydrochloride) -Suspected
Drug ineffective
Lariam (Mefloquine Hydrochloride) -Suspected
64938
02/04/1990
33
Mefloquine Hydrochloride -Suspected
Headache
Mefloquine Hydrochloride -Suspected
Malaise
Depression
Insomnia
Dizziness
Agitation
Fatigue
69065
01/01/1991
34
Mefloquine Hydrochloride -Suspected
Bradycardia
Mydriasis
Dizziness
69845
06/03/1991
29
Mefloquine Hydrochloride -Suspected
Nausea
Vomiting
Abdominal pain
Diarrhoea
71979
01/07/1991
28
Lariam (Mefloquine Hydrochloride) -Suspected
Malaise
Nausea
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
72853
09/09/1991
63
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Abdominal pain
73276
03/07/1991
28
Mefloquine Hydrochloride -Suspected
Headache
Insomnia
Dizziness
Hyperhidrosis
73281
02/07/1991
24
Mefloquine Hydrochloride -Suspected
Headache
Depression
Dizziness
Palpitations
73284
02/07/1991
40
Mefloquine Hydrochloride -Suspected
Depression
Headache
Insomnia
Dizziness
Palpitations
73286
02/07/1991
23
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Dizziness
Vomiting
74056
13/11/1991
35
Mefloquine Hydrochloride -Suspected
Ataxia
Nordette NOS (Ethinylestradiol-Levonorgestrel)
Dizziness
-Other drug
Salazopyrin (Sulfasalazine) -Other drug
74370
26/11/1991
70
Mefloquine Hydrochloride -Suspected
Nausea
Dizziness
74693
12/12/1991
45
Mefloquine Hydrochloride -Suspected
Photosensitivity reaction
75113
17/01/1992
22
Lariam (Mefloquine Hydrochloride) -Suspected
Headache
Asthenia
Flatulence
Dizziness
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
75140
16/01/1992
27
Mefloquine Hydrochloride -Suspected
Urticaria
Stevens-Johnson syndrom
76527
08/04/1992
68
Mefloquine Hydrochloride -Suspected
Flatulence
Dyspepsia
Pancreatitis
Abdominal pain
77132
15/05/1992
29
Mefloquine Hydrochloride -Suspected
Dizziness
78871
26/08/1992
29
Mefloquine Hydrochloride -Suspected
Depersonalisation/dereali
disorder
Dizziness
79546
16/09/1992
25
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Brevinor (Ethinylestradiol-Norethisterone) -Other
drug
80185
02/10/1992
33
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Anxiety
Nausea
Vertigo
80585
26/10/1992
34
Lariam (Mefloquine Hydrochloride) -Suspected
Dizziness
80894
12/11/1992
47
Lariam (Mefloquine Hydrochloride) -Suspected
Dizziness
Abdominal pain
Confusional state
81785
05/01/1993
35
Lariam (Mefloquine Hydrochloride) -Suspected
Paranoia
Nightmare
82284
02/02/1993
62
Lariam (Mefloquine Hydrochloride) -Suspected
Gravitational oedema
Isoptin (Verapamil Hydrochloride) -Other drug
Levothyroxine Sodium -Other drug
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
83229
16/03/1993
28
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Dizziness
Diarrhoea
83231
16/03/1993
31
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Dizziness
Diarrhoea
83424
23/03/1993
23
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Nightmare
83540
24/03/1993
22
Lariam (Mefloquine Hydrochloride) -Suspected
Coordination abnormal
Depression
Tremor
Dizziness
Tachycardia
Nightmare
83698
31/03/1993
41
Mefloquine Hydrochloride -Suspected
Hallucination
83926
08/04/1993
33
Mefloquine Hydrochloride -Suspected
Pyrexia
Confusional state
83927
08/04/1993
29
Mefloquine Hydrochloride -Suspected
Headache
Nausea
Abdominal pain
85085
07/06/1993
27
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Dizziness
Vertigo
Diarrhoea
85373
18/06/1993
40
Mefloquine Hydrochloride -Suspected
Insomnia
Hyperkinesia
Palpitations
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
85378
18/06/1993
40
Mefloquine Hydrochloride -Suspected
Headache
Insomnia
Palpitations
86344
30/07/1993
61
Lariam (Mefloquine Hydrochloride) -Suspected
Rash maculo-papular
Moduretic (Amiloride
Pruritus
Hydrochloride-hydrochlorothiazide) -Other drug
Premarin (Oestrogens Conjugated) -Other drug
86831
16/08/1993
57
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Dizziness
Diarrhoea
88689
25/10/1993
38
Lariam (Mefloquine Hydrochloride) -Suspected
Electrocardiogram abnorm
Brevinor-1 (Ethinylestradiol-Norethisterone)
Chest pain
-Other drug
Dyspnoea
Palpitations
89743
09/12/1993
37
Lariam (Mefloquine Hydrochloride) -Suspected
Ataxia
Scop (Hyoscine NOS) -Suspected
Bradycardia
Visual impairment
Dry mouth
89847
14/12/1993
??
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Nausea
Dizziness
Dry mouth
Diarrhoea
90115
24/12/1993
24
Lariam (Mefloquine Hydrochloride) -Suspected
Chest pain
Nausea
Dizziness
Abdominal pain
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
90882
03/02/1994
20
Chloroquine -Suspected
Headache
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Myalgia
Vomiting
Flushing
91021
11/02/1994
11
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Nausea
Agitation
91250
23/02/1994
??
Lariam (Mefloquine Hydrochloride) -Suspected
Headache
Fatigue
Rhinitis
Epistaxis
91678
18/03/1994
29
Lariam (Mefloquine Hydrochloride) -Suspected
Oesophagitis ulcerative
Dysphagia
92866
13/05/1994
30
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Visual impairment
Dizziness
Seizure
93690
14/06/1994
55
Lariam (Mefloquine Hydrochloride) -Suspected
Hyperhidrosis
Levothyroxine Sodium -Other drug
Palpitations
Renitec (Enalapril Maleate) -Other drug
93766
17/06/1994
28
Lariam (Mefloquine Hydrochloride) -Suspected
Nightmare
Oral Contraceptive NOS -Other drug
94364
11/07/1994
47
Lariam (Mefloquine Hydrochloride) -Suspected
Insomnia
Dizziness
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
94469
19/07/1994
26
Lariam (Mefloquine Hydrochloride) -Suspected
Angioedema
Dyspnoea
Vomiting
Stridor
95010
15/08/1994
43
Lariam (Mefloquine Hydrochloride) -Suspected
Chest pain
Dyspepsia
Abdominal pain
95021
12/08/1994
40
Lariam (Mefloquine Hydrochloride) -Suspected
Angioedema
Penicillin NOS -Suspected
Rash erythematous
Pruritus
Havrix (Hepatitis A Vaccine) -Other drug
Sabin Vaccine (Poliomyelitis Virus Vaccine Oral)
-Other drug
Tetanus Toxoid Vaccine Adsorbed -Other drug
95057
15/08/1994
22
Lariam (Mefloquine Hydrochloride) -Suspected
Aggression
Hepatitis A Vaccine -Other drug
Psychotic disorder
Depersonalisation/dereali
Hepatitis B Vaccine -Other drug
disorder
Meningococcal Vaccine -Other drug
Hallucination
Sabin Vaccine (Poliomyelitis Virus Vaccine Oral)
Hepatic function abnorma
-Other drug
Typhoid Oral Vaccine -Other drug
Yellow Fever Vaccine -Other drug
95568
01/09/1994
35
Mefloquine Hydrochloride -Suspected
Agitation
Nightmare
95569
01/09/1994
35
Mefloquine Hydrochloride -Suspected
Ataxia
Depression
Dizziness
Vertigo
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
95570
01/09/1994
36
Mefloquine Hydrochloride -Suspected
Ataxia
Depression
Dizziness
Vertigo
96578
14/10/1994
40
Mefloquine Hydrochloride -Suspected
Abdominal pain
Duodenal ulcer haemorrh
97218
21/11/1994
38
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Speech disorder
Vomiting
Abdominal pain
Hallucination
Diarrhoea
101728
22/06/1995
71
Lariam (Mefloquine Hydrochloride) -Suspected
Nightmare
Polaramine (Dexchlorpheniramine Maleate)
-Other drug
101845
30/06/1995
40
Mefloquine Hydrochloride -Suspected
Dysphagia
Depersonalisation/dereali
disorder
Hot flush
Palpitations
102349
24/07/1995
21
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Depression
Insomnia
Hyperkinesia
Agitation
Drug ineffective
102513
31/07/1995
24
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Agitation
Hallucination
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
103080
28/08/1995
31
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Insomnia
Dizziness
103576
15/09/1995
29
Lariam (Mefloquine Hydrochloride) -Suspected
Rash
103581
15/09/1995
30
Lariam (Mefloquine Hydrochloride) -Suspected
Urticaria
103979
11/10/1995
34
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Microgynon (Ethinylestradiol-Levonorgestrel)
Disturbance in attention
-Suspected
Agitation
Nightmare
Abnormal dreams
Hyperhidrosis
Affect lability
106386
09/02/1996
48
Lariam (Mefloquine Hydrochloride) -Suspected
Ataxia
Depression
Nightmare
Affect lability
106413
12/02/1996
44
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Anxiety
Insomnia
Depersonalisation/dereali
disorder
Paranoia
Agitation
Decreased appetite
Pharyngitis
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
106422
13/02/1996
38
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Normison (Temazepam) -Other drug
Dizziness
Nightmare
Tinnitus
Palpitations
Hallucination
106425
12/02/1996
15
Lariam (Mefloquine Hydrochloride) -Suspected
Generalised tonic-clonic
seizure
Nausea
Vomiting
Diarrhoea
106454
15/02/1996
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Headache
Tremor
Vomiting
Diarrhoea
106455
15/02/1996
9
Lariam (Mefloquine Hydrochloride) -Suspected
Nightmare
Havrix (Hepatitis A Vaccine) -Other drug
106490
16/02/1996
51
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Alpha-tocopherol -Other drug
Bronchospasm
Dizziness
Evening Primrose Oil -Other drug
Dyspnoea
Multivitamins (Vitamin Preparation Compound)
-Other drug
106634
22/02/1996
29
Lariam (Mefloquine Hydrochloride) -Suspected
Headache
Rash
Constipation
Dizziness
Pruritus
106637
23/02/1996
24
Lariam (Mefloquine Hydrochloride) -Suspected
Nightmare
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
106964
08/03/1996
62
Lariam (Mefloquine Hydrochloride) -Suspected
Pollakiuria
Pain
Anxiety
Tremor
Dizziness
Tachycardia
Vertigo
Fatigue
Diarrhoea
108641
23/05/1996
30
Mefloquine Hydrochloride -Suspected
Confusional state
Hepatitis A Vaccine -Other drug
Typhoid Vaccine -Other drug
109874
11/07/1996
27
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Depression
Nightmare
Abdominal pain
110962
20/08/1996
31
Hepatitis A Vaccine -Suspected
Anxiety
Mefloquine Hydrochloride -Suspected
Throat tightness
Insomnia
Dizziness
Agitation
Vomiting
111222
27/08/1996
27
Brevinor (Ethinylestradiol-Norethisterone)
Depression
-Suspected
Anxiety
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Agitation
Apathy
Palpitations
Affect lability
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
111771
23/09/1996
51
Imodium (Loperamide Hydrochloride) -Suspected
Hepatitis cholestatic
Lariam (Mefloquine Hydrochloride) -Suspected
Pyrexia
Noroxin (Norfloxacin) -Suspected
Vancomycin Hydrochloride -Suspected
111813
24/09/1996
47
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Accommodation disorder
Hallucination
112586
28/10/1996
39
Lariam (Mefloquine Hydrochloride) -Suspected
Paraesthesia
Microgynon (Ethinylestradiol-Levonorgestrel)
Salivary hypersecretion
-Other drug
Salazopyrin (Sulfasalazine) -Other drug
Vibra-tabs 50 (Doxycycline Hyclate) -Other drug
112602
28/10/1996
62
Lariam (Mefloquine Hydrochloride) -Suspected
Hallucination
113223
19/11/1996
28
Lariam (Mefloquine Hydrochloride) -Suspected
Ataxia
Depression
Anxiety
Paraesthesia
Headache
Nausea
Arthralgia
Dizziness
Vertigo
Palpitations
Confusional state
114149
24/12/1996
52
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Nausea
Nightmare
114298
06/01/1997
27
Lariam (Mefloquine Hydrochloride) -Suspected
Dizziness
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
114966
05/02/1997
30
Lariam (Mefloquine Hydrochloride) -Suspected
Ataxia
Coordination abnormal
Anxiety
Psychotic disorder
115298
17/02/1997
16
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Depression
Suicide attempt
Depersonalisation/dereali
disorder
Paranoia
115576
25/02/1997
35
Mefloquine Hydrochloride -Suspected
Coordination abnormal
Weight decreased
Anxiety
Sleep disorder
Myalgia
Vomiting
Thinking abnormal
Leukopenia
Decreased appetite
Diarrhoea
Hypertension
Confusional state
115639
28/02/1997
22
Lariam (Mefloquine Hydrochloride) -Suspected
Asthenia
Dyspnoea
Muscle twitching
Syncope
116276
24/03/1997
22
Cannabis Preparation -Suspected
Psychotic disorder
Mefloquine Hydrochloride -Suspected
Tremor
Delusion
Agitation
Alcohol intolerance
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
116777
15/04/1997
40
Lariam (Mefloquine Hydrochloride) -Suspected
Malaise
Depersonalisation/dereali
disorder
Dizziness
117967
30/05/1997
30
Mefloquine Hydrochloride -Suspected
Nausea
Depersonalisation/dereali
disorder
Dizziness
118190
11/06/1997
41
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Immunoglobulin - Normal (Immunoglobulin
Euphoric mood
Human Normal) -Other drug
Affect lability
119117
16/07/1997
22
Lariam (Mefloquine Hydrochloride) -Suspected
Hallucination
120656
15/09/1997
14
Lariam (Mefloquine Hydrochloride) -Suspected
Headache
Nausea
Hallucination
122287
11/11/1997
51
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Agitation
Neurosis
122360
14/11/1997
30
Gastro-stop (Loperamide Hydrochloride)
Rash
-Suspected
Pruritus
Lariam (Mefloquine Hydrochloride) -Suspected
Sinequan (Doxepin Hydrochloride) -Other drug
123232
10/12/1997
23
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Insomnia
Amoxicillin Sodium -Other drug
Paranoia
Pulmicort (Budesonide) -Other drug
Confusional state
Ventolin (Salbutamol) -Other drug
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
123239
09/12/1997
68
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Constipation
Vomiting
Diarrhoea
124176
19/01/1998
??
Lariam (Mefloquine Hydrochloride) -Suspected
Psychotic disorder
Fatigue
124271
21/01/1998
??
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Alopecia
125201
23/02/1998
43
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Depression
Nausea
Insomnia
Thinking abnormal
125233
24/02/1998
67
Lariam (Mefloquine Hydrochloride) -Suspected
Vasculitis
126827
20/04/1998
30
Lariam (Mefloquine Hydrochloride) -Suspected
Angioedema
Dry mouth
129008
08/07/1998
18
Lariam (Mefloquine Hydrochloride) -Suspected
Aggression
Psychotic disorder
129852
03/08/1998
26
Lariam (Mefloquine Hydrochloride) -Suspected
Withdrawal syndrome
Tachycardia
130352
20/08/1998
53
Lariam (Mefloquine Hydrochloride) -Suspected
Chills
Premarin (Oestrogens Conjugated) -Other drug
Nausea
Disturbance in attention
Provera (Medroxyprogesterone Acetate) -Other
drug
Dizziness
Vomiting
Decreased appetite
Flushing
131343
16/09/1998
25
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
134254
14/12/1998
??
Mefloquine Hydrochloride -Suspected
Nausea
Abdominal pain
Hepatic function abnorma
136326
18/02/1999
??
Mefloquine Hydrochloride -Suspected
Rash maculo-papular
137945
30/03/1999
??
Lariam (Mefloquine Hydrochloride) -Suspected
Malaise
Asthenia
Depression
Chest pain
Tremor
Suicide attempt
Insomnia
Nausea
Dyspnoea
Agitation
Crying
139728
21/05/1999
27
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Anxiety
Palpitations
144297
01/10/1999
??
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Aggression
Depression
Headache
Abdominal pain
Thinking abnormal
144740
18/10/1999
27
Mefloquine Hydrochloride -Suspected
Skin ulcer
Rash maculo-papular
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
145869
16/11/1999
27
ADT Booster (Diphtheria And Tetanus Vaccine
Headache
NOS) -Suspected
Nausea
Lariam (Mefloquine Hydrochloride) -Suspected
Dizziness
M-M-R II (Measles, Mumps, Rubella Vaccine)
Abdominal pain
-Suspected
Hyperhidrosis
Sabin Vaccine (Poliomyelitis Virus Vaccine Oral)
Pyrexia
-Suspected
Syncope
Stamaril (Yellow Fever Vaccine) -Suspected
Testicular disorder
Typhim VI (Typhoid Vaccine) -Suspected
147627
04/01/2000
37
Lariam (Mefloquine Hydrochloride) -Suspected
Delirium
Psychotic disorder
Delusion
Paranoia
Pyrexia
Rash maculo-papular
Neurosis
Confusional state
148799
10/02/2000
50
Lariam (Mefloquine Hydrochloride) -Suspected
Pain
Nausea
Pyrexia
149626
25/02/2000
40
Lariam (Mefloquine Hydrochloride) -Suspected
Chills
Pyrexia
149742
29/02/2000
53
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Mania
Psychotic disorder
Schizophreniform disorde
Delusion
Nightmare
Hallucination
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
150241
10/03/2000
46
Lariam (Mefloquine Hydrochloride) -Suspected
Asthenia
Delirium
Tremor
Pyrexia
150242
10/03/2000
24
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Insomnia
Paranoia
Agitation
154010
22/06/2000
55
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Headache
Nausea
Urinary incontinence
Nightmare
Hypertension
Diarrhoea
154180
26/06/2000
29
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Depression
154477
06/07/2000
27
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Vomiting
Hepatic function abnorma
154564
06/07/2000
5
Lariam (Mefloquine Hydrochloride) -Suspected
Headache
155330
12/07/2000
24
Lariam (Mefloquine Hydrochloride) -Suspected
Withdrawal syndrome
Headache
PWTRAN01
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Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
157185
31/08/2000
46
Fansidar (Pyrimethamine; Sulfadoxine)
Asthenia
-Suspected
Headache
Lariam (Mefloquine Hydrochloride) -Suspected
Hypokinesia
Primaquine Phosphate -Suspected
Visual impairment
Encephalopathy
Confusional state
Photophobia
Hyperaesthesia
Seizure
157186
31/08/2000
31
Aspalgin (Aspirin; Codeine) -Suspected
Erythema multiforme
Lariam (Mefloquine Hydrochloride) -Suspected
Arthralgia
Oedema peripheral
159141
08/11/2000
50
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Nausea
Myopathy
Affect lability
Diarrhoea
159554
27/11/2000
40
Lariam (Mefloquine Hydrochloride) -Suspected
Vomiting
Salivary hypersecretion
160395
04/01/2001
32
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
163176
30/03/2001
22
Lariam (Mefloquine Hydrochloride) -Suspected
Urticaria
Tremor
Depersonalisation/dereali
disorder
Dysphonia
164195
03/05/2001
??
Lariam (Mefloquine Hydrochloride) -Suspected
Seizure
PWTRAN01
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Page 19 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
164196
03/05/2001
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Suicide attempt
Sleep disorder
Agitation
Abnormal dreams
Nightmare
Seizure
167930
27/08/2001
26
Lariam (Mefloquine Hydrochloride) -Suspected
Nightmare
167931
27/08/2001
26
Lariam (Mefloquine Hydrochloride) -Suspected
Withdrawal syndrome
Depression
Headache
Skin exfoliation
Agitation
Tinnitus
Palpitations
168290
10/09/2001
31
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Back pain
Dizziness
Myalgia
Nightmare
Abdominal pain
Decreased appetite
176672
26/06/2002
37
Hepatitis A Vaccine -Suspected
Anxiety
Mefloquine Hydrochloride -Suspected
Agitation
Paranoia
Sabin Vaccine (Poliomyelitis Virus Vaccine Oral)
-Suspected
Fatigue
Hyperhidrosis
Yellow Fever Vaccine -Suspected
Palpitations
Confusional state
PWTRAN01
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Page 20 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
177412
23/07/2002
43
Lariam (Mefloquine Hydrochloride) -Suspected
Psychotic disorder
Levothyroxine Sodium -Other drug
Agitation
Fatigue
Zoloft (Sertraline Hydrochloride) -Other drug
Confusional state
178500
26/08/2002
36
Lariam (Mefloquine Hydrochloride) -Suspected
Rash
Havrix 1440 (Hepatitis A Vaccine) -Other drug
Arthralgia
Jaundice
180971
23/12/2002
27
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Insomnia
Rash papular
Dizziness
186149
22/05/2003
48
Lariam (Mefloquine Hydrochloride) -Suspected
Abdominal distension
Paraesthesia
Dizziness
Flushing
189177
04/08/2003
44
Lariam (Mefloquine Hydrochloride) -Suspected
Ataxia
Headache
Dizziness
Nightmare
189660
19/08/2003
50
Lariam (Mefloquine Hydrochloride) -Suspected
Arrhythmia supraventricul
Chest pain
Sinus bradycardia
190643
19/09/2003
50
Lariam (Mefloquine Hydrochloride) -Suspected
Bradycardia
Extrasystoles
192300
18/11/2003
??
Lariam (Mefloquine Hydrochloride) -Suspected
Rash
Nausea
Agitation
Heart rate decreased
Dizziness
Emotional disorder
PWTRAN01
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Page 21 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
192301
18/11/2003
??
Lariam (Mefloquine Hydrochloride) -Suspected
Rash
Nausea
Agitation
Dizziness
Heart rate decreased
Emotional disorder
Pruritus
193035
10/12/2003
34
Mefloquine Hydrochloride -Suspected
Cognitive disorder
Insomnia
Visual impairment
Feeling of despair
Abnormal dreams
Feeling abnormal
193091
12/12/2003
??
Lariam (Mefloquine Hydrochloride) -Suspected
Delusion
Hallucination
193808
12/01/2004
28
Mefloquine Hydrochloride -Suspected
Illusion
Agitation
Paranoia
196205
03/04/2004
27
Lariam (Mefloquine Hydrochloride) -Suspected
Vaginal haemorrhage
Abortion spontaneous
196357
08/04/2004
32
Mefloquine Hydrochloride -Suspected
Temporal lobe epilepsy
Abnormal dreams
Seizure
196788
27/04/2004
32
Japanese Encephalitis Vaccine -Suspected
Urticaria
Lariam (Mefloquine Hydrochloride) -Suspected
Lip swelling
Pruritus
Merieux Inactivated Rabies Vaccine (Rabies
Vaccine-merieux Hdcv) -Suspected
PWTRAN01
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Page 22 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
197051
06/05/2004
42
Lariam (Mefloquine Hydrochloride) -Suspected
Oropharyngeal pain
Nausea
Dysphagia
Dizziness
Gastrooesophageal reflux
disease
Vomiting
Hallucination
Pruritus
Mouth ulceration
199121
19/07/2004
10
Mefloquine Hydrochloride -Suspected
Nervousness
Anxiety
Feeling cold
Social avoidant behaviour
199611
03/08/2004
??
Lariam (Mefloquine Hydrochloride) -Suspected
Suicidal ideation
203093
26/11/2004
??
Lariam (Mefloquine Hydrochloride) -Suspected
Dizziness
Syncope
205762
04/03/2005
23
Lariam (Mefloquine Hydrochloride) -Suspected
Haemolytic anaemia
Headache
Nausea
Dizziness
Myalgia
Alopecia
Vomiting
Cardiac murmur
206956
13/04/2005
17
Lariam (Mefloquine Hydrochloride) -Suspected
Suicidal ideation
207002
13/04/2005
33
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Hallucination, auditory
Bradyphrenia
214632
05/01/2006
16
Lariam (Mefloquine Hydrochloride) -Suspected
Suicidal ideation
PWTRAN01
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Page 23 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
215711
10/02/2006
3
Mefloquine Hydrochloride -Suspected
Nightmare
218958
06/06/2006
29
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Mental disorder
Sleep disorder
Mood swings
227285
03/04/2007
21
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Dyspnoea
Palpitations
229467
06/06/2007
??
Lariam (Mefloquine Hydrochloride) -Suspected
Hepatitis acute
229989
20/06/2007
24
Lariam (Mefloquine Hydrochloride) -Suspected
Hepatic failure
Levlen ED (Ethinylestradiol-Levonorgestrel)
Jaundice
-Other drug
230298
28/06/2007
51
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Vomiting
Nightmare
Diarrhoea
Seizure
236536
27/12/2007
??
Lariam (Mefloquine Hydrochloride) -Suspected
Mania
Antidepressant NOS -Other drug
236571
31/12/2007
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Malaise
Anxiety
Disturbance in attention
Nausea
Dysarthria
Palpitations
237733
08/02/2008
22
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Paranoia
PWTRAN01
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Page 24 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
240182
21/04/2008
26
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Marvelon (Ethinylestradiol-Desogestrel)
Diarrhoea
-Suspected
Menstrual disorder
243848
15/08/2008
29
Mefloquine Hydrochloride -Suspected
Vision blurred
Gait disturbance
Disturbance in attention
Hypoaesthesia
Feeling abnormal
Hallucination
244949
29/09/2008
27
Lariam (Mefloquine Hydrochloride) -Suspected
Chest pain
Home Brand Ibuprofen (Ibuprofen) -Other drug
Seizure
249549
24/03/2009
20
Mefloquine Hydrochloride -Suspected
Depression
Anxiety
249639
25/03/2009
19
Mefloquine Hydrochloride -Suspected
Headache
Paraesthesia
Anxiety
Depression
Memory impairment
Nausea
Gait disturbance
Panic attack
Retching
Dizziness
Balance disorder
Vertigo
Nightmare
Abnormal dreams
Confusional state
PWTRAN01
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Page 25 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
255109
08/08/2009
28
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Vision blurred
Nausea
Panic attack
Hyperventilation
Agitation
Dizziness
Agoraphobia
Abdominal pain
255164
08/08/2009
17
Lariam (Mefloquine Hydrochloride) -Suspected
Migraine
Inderal (Propranolol Hydrochloride) -Other drug
Spironolactone -Other drug
255291
12/08/2009
32
Lariam (Mefloquine Hydrochloride) -Suspected
Panic attack
Palpitations
Hallucination
Feeling abnormal
263023
22/02/2010
45
Lariam (Mefloquine Hydrochloride) -Suspected
Urticaria
Pharyngeal oedema
283365
27/05/2011
16
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Drop attacks
Insomnia
Dizziness
Alopecia
Nightmare
305722
21/08/2012
31
Lariam (Mefloquine Hydrochloride) -Suspected
Headache
Somnolence
PWTRAN01
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Page 26 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
311669
20/12/2012
83
Ciprofloxacin -Suspected
Rash
Mefloquine Hydrochloride -Suspected
Urine output decreased
Toxicity to various agents
Aspirin -Other drug
Acute kidney injury
Digoxin -Other drug
Muscle twitching
Flecainide Acetate -Other drug
Prazosin Hydrochloride -Other drug
320125
22/05/2013
1
Lariam (Mefloquine Hydrochloride) -Suspected
Pyrexia
Screaming
Lethargy
328599
14/10/2013
35
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Anxiety
Completed suicide
Affect lability
331190
18/11/2013
54
Mefloquine Hydrochloride -Suspected
Tremor
Nausea
Panic attack
Dizziness
Fatigue
339087
23/04/2014
43
Lariam (Mefloquine Hydrochloride) -Suspected
Suicidal ideation
339089
23/04/2014
41
Lariam (Mefloquine Hydrochloride) -Suspected
Parasomnia
Levlen ED (Ethinylestradiol-Levonorgestrel)
-Other drug
Levothyroxine Sodium -Other drug
342131
16/06/2014
??
Lariam (Mefloquine Hydrochloride) -Suspected
Alopecia
Dyspepsia
343288
07/07/2014
??
Lariam (Mefloquine Hydrochloride) -Suspected
Completed suicide
Feeling abnormal
PWTRAN01
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Page 27 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
343294
07/07/2014
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Anxiety
Abortion spontaneous
Panic attack
Mood altered
Maternal exposure during
pregnancy
355027
24/02/2015
29
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Insomnia
Dizziness
Vomiting
361684
17/06/2015
??
Mefloquine Hydrochloride -Suspected
Mental disorder
Post-traumatic stress diso
363605
09/07/2015
24
Mefloquine Hydrochloride -Suspected
Pruritus
Maternal exposure during
pregnancy
364545
27/07/2015
19
Lariam (Mefloquine Hydrochloride) -Suspected
Psychotic disorder
369496
26/10/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Mental disorder
General physical health
deterioration
370277
05/11/2015
19
Mefloquine Hydrochloride -Suspected
Depression
Anxiety
Bipolar disorder
Abnormal dreams
371339
25/11/2015
57
Hepatitis A Vaccine -Suspected
Urticaria
Lariam (Mefloquine Hydrochloride) -Suspected
Yellow Fever Vaccine -Other drug
PWTRAN01
Report Printed :
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Page 28 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
371834
03/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Nausea
Dizziness
Abdominal pain
Seizure
371888
04/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Depression
Anxiety
Paranoia
Suicidal ideation
Mental impairment
372233
09/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Abnormal behaviour
Sleep paralysis
Anxiety
Depression
Mood swings
372953
08/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Insomnia
Vertigo
Loss of consciousness
Post-traumatic stress diso
372975
10/12/2015
65
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Acrophobia
Depression
Emotional distress
Balance disorder
Suicidal ideation
Feeling abnormal
Confusional state
Decreased interest
PWTRAN01
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Page 29 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
373215
15/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Depression
Auditory disorder
Nausea
Mental disorder
Nightmare
Suicidal ideation
373243
15/12/2015
??
Mefloquine Hydrochloride -Suspected
Hallucination, auditory
Mefloquine Hydrochloride -Other drug
373477
22/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Anxiety
Nightmare
373659
29/12/2015
30
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Depression
Anxiety
Brain injury
General physical health
deterioration
Viral infection
373666
29/12/2015
??
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Abnormal behaviour
Anxiety
Mood swings
377346
14/03/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Violence-related symptom
Hallucination
PWTRAN01
Report Printed :
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Page 30 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
377737
21/03/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Suicide attempt
Mental disorder
Overdose
Mood altered
Post-traumatic stress diso
386737
21/04/2016
48
Lariam (Mefloquine Hydrochloride) -Suspected
Condition aggravated
387042
28/04/2016
69
Lariam (Mefloquine Hydrochloride) -Suspected
Muscular weakness
Chills
Acute psychosis
Balance disorder
Hyperhidrosis
Suicidal ideation
389932
10/06/2016
23
Lariam (Mefloquine Hydrochloride) -Suspected
Seizure
393415
15/08/2016
0
Lariam (Mefloquine Hydrochloride) -Suspected
Limb reduction defect
Foetal exposure during
pregnancy
394154
29/08/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Mental disorder
Completed suicide
Mental impairment
394155
29/08/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Mental disorder
394252
30/08/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Homicidal ideation
Tremor
Mental disorder
Flashback
Violence-related symptom
Suicidal ideation
PWTRAN01
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Page 31 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
394265
30/08/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Psychotic disorder
Suicide attempt
Contraindicated product
administered
395358
16/09/2016
11
Lariam (Mefloquine Hydrochloride) -Suspected
Sleep terror
Dysphagia
Panic attack
Eating disorder
396739
11/10/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Mental disorder
396753
11/10/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Phobia
Vertigo
Nightmare
400568
12/12/2016
??
Lariam (Mefloquine Hydrochloride) -Suspected
Paraesthesia
Malaria
Weight abnormal
Eating disorder
Drug ineffective
400675
13/12/2016
45
Lariam (Mefloquine Hydrochloride) -Suspected
Demyelination
Chronic fatigue syndrome
Migraine
Blood disorder
Sjogren's syndrome
Fibromyalgia
Nausea
Disturbance in attention
Encephalitis
Suicidal ideation
Photosensitivity reaction
Feeling abnormal
Hypoacusis
PWTRAN01
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Page 32 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
400812
15/12/2016
55
Lariam (Mefloquine Hydrochloride) -Suspected
Depression
Post-traumatic stress diso
402849
30/01/2017
??
Mefloquine Hydrochloride -Suspected
Hallucination, visual
Paranoia
Physical assault
403234
07/02/2017
32
Lariam (Mefloquine Hydrochloride) -Suspected
Weight decreased
Tremor
Nausea
Tinnitus
Decreased appetite
403844
18/02/2017
45
Mefloquine Hydrochloride -Suspected
Panic attack
Vertigo
Nightmare
Thinking abnormal
403856
19/02/2017
42
Lariam (Mefloquine Hydrochloride) -Suspected
Hallucination, visual
Depression
Anxiety
Headache
Insomnia
Disturbance in attention
Retinal vein occlusion
Blindness unilateral
Tinnitus
Vertigo
404028
22/02/2017
38
Mefloquine Hydrochloride -Suspected
Aggression
Suicidal ideation
PWTRAN01
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Page 33 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
404308
27/02/2017
18
Mefloquine Hydrochloride -Suspected
Stress
Bipolar disorder
Dizziness
Vertigo
Tinnitus
405066
09/03/2017
40
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Depression
Anxiety
Paraesthesia
Disturbance in attention
405180
14/03/2017
21
Lariam (Mefloquine Hydrochloride) -Suspected
Ill-defined disorder
407707
21/04/2017
??
Mefloquine Hydrochloride -Suspected
Completed suicide
410559
26/05/2017
60
Lariam (Mefloquine Hydrochloride) -Suspected
Major depression
Ill-defined disorder
414042
13/07/2017
32
Lariam (Mefloquine Hydrochloride) -Suspected
Anxiety
Insomnia
Abnormal dreams
418352
18/09/2017
??
Lariam (Mefloquine Hydrochloride) -Suspected
Post-traumatic stress diso
PWTRAN01
Report Printed :
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Page 34 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
418355
18/09/2017
??
Unknown
Lariam (Mefloquine Hydrochloride) -Suspected
Amnesia
Muscular weakness
Disorientation
Oropharyngeal pain
Abnormal behaviour
Night sweats
Endolymphatic hydrops
Headache
Anxiety
Malaise
Emotional distress
Ear pain
Nausea
Formication
Back pain
Panic attack
Myalgia
Agitation
Anger
Paranoia
Somatic symptom disorde
Deafness
Abdominal pain upper
Mood altered
Nightmare
Fatigue
Depressed mood
Abdominal pain
Lethargy
Eyelid disorder
Decreased appetite
Thyroglossal cyst
Diarrhoea
Neck pain
PWTRAN01
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Page 35 of 36
Case Line Listing
Cases Count: 240
Report
Onset
Onset
Case No. Date
Date
State
Sex Age Outcome
Medicine
Time
Reaction
Musculoskeletal pain
Photophobia
Flushing
420659
25/10/2017
45
Mefloquine Hydrochloride -Suspected
Anxiety
Depression
Headache
Insomnia
Irritability
Abnormal dreams
Abdominal pain
Selection Parameters : Date Range: 01/01/1980 To 17/02/2018 Medicine Status: General marketing Unclear causality excluded Medicine Names: Lariam, Mefloquine Hydrochloride
PWTRAN01
Report Printed :
14/06/2018 12:26
Page 36 of 36
