Attachment A
FOI Request 2021/22-010 - Successful applications for NHMRC funding from 2016–2020 that include search terms relating to ‘migraine research’
Number Application Application Funding
Funding
Title
CIA Name
Administering State
Sector
Grant Budget Broad
Field of
Keywords
Media Summary
ID
Year
Type
Subtype
Institution
Research Research
Area
1
APP1122387
2016 Project
Standard
Identifying novel
Prof Lyn Griffiths Queensland
QLD
University
$640,966.25 Clinical
Neurogenetics migraine | population This proposal aims to identify novel FHM genes by undertaking an NGS
Grants
Project
gene mutations for
University of
Medicine
genetics | pedigree
screen of the whole exome of 209 FHM patient samples. We will test
Grant
molecular diagnosis
Technology
and
analysis | molecular
the pathological relevance of detected novel mutations by functional
of Familial
Science
genetics | sequencing
analysis in human cel models and using patient-specific stem cel
Hemiplegic Migraine
techniques. Using whole genome NGS technology to identify novel
mutations wil assist in the design and development of a
comprehensive NGS approach to diagnose and differentiate this severe
neurological disorder.
2
APP1124011
2016 Project
Standard
Coupling the
Prof Benjamin University of
QLD
University
$1,272,784.91 Basic
Developmental developmental genetics Cerebral cavernous malformations (CCMs) are thin wal ed, vascular
Grants
Project
mechanical,
Hogan
Queensland
Science
Genetics (incl. | cel signal ing |
malformations in the brain found in 1/200-250 individuals. They can
Grant
signal ing and
Sex
vascular development | cause migraine, neurological deficits or stroke. This disease can be
transcriptional
Determination) vascular pathologies | inherited due to damaging mutations in any of three CCM genes. The
mechanisms that
zebrafish
project wil investigate the molecular control of CCM pathogenesis in
initiate pathogenesis
animal models. We aim to uncover the molecular cause of these
of Cerebral
vascular malformations and in doing so identify new therapeutic
Cavernous
strategies.
Malformation
3
APP1126976
2016 Project
Standard
Ictal Characteristics A/Pr Miriam
University of
NSW
University
$288,787.66 Clinical
Sensory
vertigo | eye
vertigo is a disabling symptom affecting 1 mil ion Australians at any
Grants
Project
of Common
Welgampola
Sydney
Medicine Systems
movements | migraine | given time. Acute vertigo is associated with abnormal eye movements
Grant
Vestibular Diseases
and
meniere's disease |
or nystagmus, the pattern of which points to its origin. In this project,
Science
vestibular neuritis
we extract the unique characteristics of distinct vertigo syndromes to
enable their separation
4
APP1143547
2017 Project
Standard
Brainstem and
Prof Luke
University of
NSW
University
$674,937.74 Basic
Central Nervous migraine | brain imaging Migraine is a disabling condition characterized by mostly unilateral
Grants
Project
hypothalamic
Henderson
Sydney
Science
System
| functional magnetic
throbbing head pain and a range of associated neurological symptoms.
Grant
function and
resonance imaging
The underlying mechanisms responsible for the initiation of migraine
anatomy in Migraine
(fmri) | brainstem |
remains unknown. We aim to determine brain anatomy and activity
hypothalamus
patterns in migraineurs throughout the migraine cycle. An
understanding of the mechanisms responsible for migraine wil aid in
better treatment development.
5
APP1159006
2018 Project
Standard
A structural
Dr Yi-Lynn Liang Monash
VIC
University
$1,202,523.80 Basic
Structural
electron microscopy | The calcitonin-family receptor are physiological y important receptors
Grants
Project
understanding of
University
Science
Biology (incl.
signal ing pathways | g that have been implicated in treatment of osteoporosis, migraine and
Grant
calcitonin gene-
Macromolecular protein-coupled
cardiovascular diseases. Therapeutic development targeting at these
related peptide and
Model ing)
receptors | structure-
receptors remains chal enging due to lack of mechanistic understanding
adrenomedullin
function | calcitonin
in how these GPCRs are activated. This proposal wil explore the
function
receptor
structure and function of the calcitonin-family receptors at a molecular
level, enabling improved discovery and development of novel
therapeutics.
6
APP1161467
2018 Career
Clinical CDF Revolutionising
A/Pr Trudy
University of
NSW
University
$270,837.10 Health
Primary Health health services research In this Career Development Fel owship, I am to discover new
Developme
health service
Rebbeck
Sydney
Services Care
| musculoskeletal
mechanisms that underlie why many people with musculoskeletal pain
nt
delivery for
Research
disorders | headache | progress to have long term pain and disability. With my team, we wil
Fel owships
musculoskeletal
primary care |
investigate recovery pathways and know early on who is at risk of non-
disorders through
implementation
recovery. This wil enable us to direct health care services to those who
discovery, simplifying
need them, referring at-risk individuals to expert musculoskeletal
prognosis and
physiotherapists early after injury, thereby reducing the burden on the
implementing novel
medical system.
clinical pathways.
7
APP1164494
2018 Project
Standard
The spilt personality Prof Renae Ryan University of
NSW
University
$996,180.28 Basic
Structural
membrane transport | Membrane proteins are pumps that control the movement of nutrients,
Grants
Project
of glutamate
Sydney
Science
Biology (incl.
glutamate | chloride
waste products and chemical messengers in and out of cel s. These
Grant
transporters: the
Macromolecular channel | structural
pumps break down in a wide range of diseases including neurological
structural basis and
Model ing)
biology | drosophila
disorders and cancer. This project is focused on a unique type of
physiological role of
melanogaster
transporter/channel hybrid protein that uses a ‘twisting elevator’
a dual function
mechanism. We wil uncover how they work and what goes wrong in
transporter/channel
disease. This information can then be used to develop new drugs to
improve transporter function.
8
APP1181643
2019 Ideas Grants Ideas Grants The contribution of Dr Ehsan
Australian
ACT
University
$445,902.66 Basic
Central Nervous sensory cortex | ion
Our recent discovery that transient receptor potential Ankyrin 1
cortical TRPA1 to
Kheradpezhouh National
Science
System
channels | calcium
(TRPA1) is highly expressed in rodent cortical neurons has shed light on
sensory perception
University
signal ing | sensory
its role in the mammalian cortex. Recent studies have proposed a role
and behaviour of
function | sensory
for cortical TRPA1 in Alzheimer’s disease and migraine and further
mammals
neurons
suggested that its activation can lead to neuronal damage. We will
further investigate the physiological role of TRPA1, focusing on its
potential involvement in multisensory detection and processing.
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